I saw small signs this was helping my dog (he's 13 years old, Pitt mix, 80lbs), he was getting up a tiny bit quicker and easier then prior. I was giving it to him one time a day on the lowest amount (.25) but a week in, he wasn't eating, and he was lethargic. I stopped giving it to him and he was eating again and wasn't lethargic anymore....so it's an expensive trial and error mission.